Cisplatin is a platinum complex used as an anticancer drug for various types of cancer including testicular cancer, ovarian cancer, head and neck cancer, brain tumor and many more. The trans isomer of cisplatin, also known as transplatin, is not used to treat cancer patients. The reason lies into the process of how platinum based anticancer drugs work. Cisplatin Cisplatins attack the target DNAs of the tumor cells and inhibit their repair process and synthesis. It makes crosslinks (interstrand and intrastrand) and produces DNA adduct. There are some theories about transplatin and its function in body. It is said to be more reactive and makes unnecessary complexes before reaching the cell or target DNA. Transplatin In comparison between cisplatin and transplatin, transplatin produces much less DNA adduct than cisplatin. But both cisplatin and transplatin are cytotoxic and both should face DNA restriction while attacking. As in transplatin, the leaving groups, which are the ...